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Its already a popular ingredient in topical skin and haircare products, with manufacturers claiming it can do everything from reducing fine lines and fading hyperpigmentation to tightening loose skin

Sermorelin was FDA-approved as Geref in 1990 for pediatric growth hormone deficiency and was voluntarily discontinued by the manufacturer in 2008 for commercial reasons, not safety reasons

However, certain skincare products may increase irritation when used together: Retinoids (Tretinoin, Adapalene) May increase skin sensitivity

Tirzepatide is the older, fully matured story: a single-molecule dual incretin agonist taken from discovery through Phase 1 proof-of-concept, [7] then through the large SURPASS (diabetes) and SURMOUNT (obesity) Phase 3 programs, and finally to FDA and EMA approval