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In the fasting state, pathways downregulated in PBH included spermidine/spermine biosynthesis, tryptophan and methionine metabolism, phospholipid synthesis, and glycolysis (Figure 1B)

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Data were captured through annual labs, a connected Withings weight scale, sleep-tracking device integrations, and active member self-reporting on food intake and energy

Fasting and postprandial glucose, HbA1c, total cholesterol, high-density lipoprotein-cholesterol (HDL-C), triglycerides, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase ( GT), and uric acid and creatinine were performed by commercial kits (Labtest, Brazil)