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Furthermore, MSeA instigates a cell cycle arrest at the G1 phase, a critical checkpoint in the cell cycle, which is correlated with an upregulation in the expression of p27kip1 and p21cip1, both of which are cyclin-dependent kinase inhibitors that play a crucial role in regulating cell cycle progression (146)

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Rather, they fail within a complex, multicellular environment in which astrocytes, microglia, oligodendrocytes, vascular elements, and systemic immune components actively participate

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