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Tissue effects (angiogenesis, VEGF-receptor signaling, growth factor cross-talk) persist much longer than the plasma window

After correction using the ComBat method ( Supplementary Figures 1C, D ), dataset differences among samples significantly decreased, and the clustering structure of RA and normal control groups in principal component space became clearer, indicating that the data processing workflow effectively enhanced data quality and the reliability of subsequent analyses

Researchers are already exploring approaches such as lowering doses, taking medicines less frequently (like monthly or quarterly), or switching from injections to pills

These include bupropion combined with naltrexone , mirtazapine , modafinil , and topiramate , each showing varying degrees of efficacy in early studies