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Hemochromatosis: pathophysiology, evaluation, and management of hepatic iron overload with a focus on MRI

By activating both receptors simultaneously, it appears to restore GIP sensitivity in diabetic patients something researchers did not expect

While it is still important to make sure those cases are biopsied appropriately in the nail matrix and sent for evaluation with experienced dermatopathologists, these are not the cases that serve as a diagnostic challenge

designed a nanoplatform (AS_LIG@PPGC NPs) co-encapsulating astragaloside IV (AS) and ligustrazine (LIG), which demonstrated potent anti-fibrotic efficacy through dual-pathway suppression of NOX4-mediated ROS/p38 MAPK and NLRP3 signaling, reducing ROS generation while disrupting the self-amplifying loop between NOX4 activation and inflammasome formation (Zheng et al., 2024)