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The ANT crystal structures in both cytoplasmic-open (c-state) and matrix-open states (m-state) locked by two inhibitors bound at the solute binding site, carboxyatractyloside and bongkrekic acid respectively, highlighted a conserved alternating-access transport mechanism 5 enabled by the conformational change upon solute binding at the central cavity 6,7
The FDA issues warning letters requiring the company to cease prohibited marketing claims, reformulate the product, or stop selling it entirely
It also plays a critical role in the liver, where it helps the body process and eliminate environmental toxins
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