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Studies in IBD models show KPV reduces secretion of TNF-, IL-1, and IL-6 from both intestinal epithelial cells and macrophages.13 It also appears to modulate MAPK signaling specifically the ERK/p38 axis which regulates cell stress, apoptosis, and inflammatory gene expression.4 What KPV Does Not Do It does not suppress the immune system broadly

le Roux CW, Steen O, Lucas KJ, Startseva E, Unseld A, Hennige AM