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(3) Consequently, the upregulated growth hormone release may interact with growth hormone receptors in a variety of cells, which may synthesize a major anabolic mediator called insulin-like growth factor-1 (IGF-1)

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For the principal component analysis (PCA) the variance was filtered by default optimisation settings and a predefined standard deviation of p = 0.005 comparing untreated HepG2 and HepG2 ATP7B-KO cells resulted in a false discovery rate (FDR) of q = 0.01788