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It is also present in significant amounts in the lungs, kidneys, intestinal lining, and immune cells

Furthermore, these nanocarriers are capable of depleting GSH levels in the tumor microenvironment to augment stress on cells and induce cell death pathways, including ferroptosis, making cancer cells sensitive to treatment Fig

These levels can still induce gluconeogenesis and lipolysis

The DNAPK complex also serves as a key regulator of hyperglycemia-induced endothelial ferroptosis in T2DM cardiomyopathy, potentially representing a novel therapeutic strategy to alleviate T2DM microvascular dysfunction and cardiac dysfunction [97]