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Empirical evidence suggests that exposure to blue light or white light with a high correlated color temperature (CCT) during nighttime significantly suppresses melatonin production, resulting in delayed circadian rhythms, diminished sleep quality, and circadian rhythm disorders (61, 62)
536,537 Moreover, TMAO affects liver physiology by modulating macrophage metabolic remodeling, reducing matrix metalloproteinase 12 levels, which impairs macrophage migration and delays liver regeneration following AILI
Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17
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