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Contact your GP or prescribing clinician if you experience cold intolerance accompanied by other symptoms that might suggest thyroid dysfunction, such as: Extreme fatigue or weakness that interferes with daily activities Unexplained weight gain or cessation of weight loss despite adherence to treatment Significant hair loss or changes in hair texture Persistent constipation unresponsive to usual measures Dry, flaky skin or changes in skin texture Muscle aches, cramps, or weakness Slowed heart rate Depression or significant mood changes Cognitive difficulties, including memory problems or difficulty concentrating These symptoms could indicate hypothyroidism , which requires investigation through thyroid function tests (TSH, free T4)
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Bray-Curtis dissimilarity analysis indicated substantial compositional divergence between groups (Figure S4A-B)
The AWARD-7 trial, which is notable for its exclusive focus on patients with moderate-to-severe chronic kidney disease, demonstrated that dulaglutide users, particularly those simultaneously using ACE inhibitors or angiotensin receptor blockers, exhibited a substantially less eGFR decline compared to insulin glargine users
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