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Notably, lactate-induced ALDH2-K52la in renal cells disrupts its interaction with PHB2, a critical mitophagy receptor, leading to PHB2 degradation, impaired mitophagy, and worsened kidney damage

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It then inhibited the activation of NF-B and increased the rate of Bcl-2/Bax genesis to further induce the onset of apoptosis

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