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Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression

Primary Research Vectors Visceral Adiposity: Studying the reduction of white adipose tissue (WAT) and the shrinkage of fat cell size without altering caloric intake in animal models

In peripheral nerves, the preferential effect on small, myelinated fibers accounts for the characteristic order of sensory loss (pain, temperature, touch, proprioception) followed by motor blockade

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