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Can usually walk with discomfort

On the other hand, it has been reported that GLP-1 receptor expression in -cells is decreased in the diabetic state 18,19 and that TCF7L2 functions as a transcription factor of GLP-1 receptor at least in -cells 20

PubMed Central, doi:10.1038/sj.bjc.6604820

[1] [3] Importantly, patients should seek urgent medical attention if they experience severe or persistent abdominal pain (especially if radiating to the back), repeated vomiting, inability to keep fluids down, signs of dehydration, or jaundice, as these may indicate serious conditions such as pancreatitis or gallbladder disease