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This non-standard amino acid has a bulkier side chain than alanine, and DPP-4 simply cannot get a grip on it

[13] In the other five trials (NCT01930188, [69] NCT01885208, [70] NCT02128932, [71] NCT02207374, [72] and NCT02254291 [73] ), participants were randomly assigned to receive either semaglutide or another anti-diabetic medication, and the participant and provider knew which medication was being given in four trials

To improve robustness for longitudinal analysis, we used principal component-based versions of the first- and second-generation clocks (denoted PC clocks) wherever applicable

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