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Each ingredient on its own is either Category A (B) or essential with no evidence of harm at normal levels (B, B, B) or Category C in very high doses (niacin)

Knee injury: one user reported no ongoing problems after using BPC-157 and TB-4, while another reported a long-standing hip injury did not fully heal despite using BPC-157 and TB-500

In 2023 the FDA placed CJC-1295 in "Category 2" of its interim 503A bulks list, meaning it identified significant safety concerns and did not permit its use in traditional pharmacy compounding

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