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Organ and Gut Growth (with misuse) Prolonged or high-dose use may lead to non-specific cell growth in internal organs or the intestines, contributing to the "roid gut" or distended abdomen effect seen in some bodybuilders

Since it's applied externally and not consumed, it doesn't affect your fasting state while providing essential hydration to your skin

Conversely, two mast cell lines do express CB1 and CB2 at both the mRNA and protein level [105] and another study detected CB2 mRNA in rat peritoneal mast cells although administration of 9 -THC dose-dependently released histamine irrespective of the CBRs [106]