gallbladder issues with glp-1 receptor agonists and disease risk: insights into molecular mechanisms and clinical implications Glucagon-like peptide-1 receptor agonist use

doi: 10.1038/s41467-021-22033-2 3 BalabanN.CirioniO.GiacomettiA.GhiselliR.BraunsteinJ

A relative shift toward increased fat and reduced carbohydrate oxidation was observed with liraglutide

Mechanisms investigated Metabolic-pathway research converges on a small set of enzymatic and receptor targets, and these compounds map onto different ones they are not interchangeable: NNMT inhibition (5-Amino-1MQ): studied as a small-molecule inhibitor of nicotinamide N-methyltransferase, an enzyme implicated in cellular NAD/SAM metabolism

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