To rapidly clear Glu from the synapse and prevent excitotoxicity, it is taken up by astrocytes and participates in a recycling cycle with its metabolic precursor, glutamine (Gln)
As a result of rapid hydrolysis, plasma concentrations of aspirin are always low and rarely exceed 20 ug/ml (111 uM) at ordinary therapeutic doses of 325 to 650 mg (Dovizio et al, 2013) Salicylate can also inhibit COX-1 and COX-2 with little selectivity if high enough plasma concentrations are achieved (Table 1)(Dovivzio et al, 2013): Salicylate IC50 for COX-1 = 1100 uM Salicylate IC50 for COX-2 = 1400 uM Salicylates are excreted mainly by the kidney
Mo X, Cheng R, Shen L, Sun Y, Wang P, Jiang G, et al
Mullally, MD By now, youve likely heard the buzz around Ozempic and other GLP-1 medications