The drug lowered levels of 2-aminoadipic acid (2-AAA), triglycerides (TGs) enriched in short- and saturated-chain fatty acids, and urate in both trial populations, while 2-hydroxybutyrate (2-HB) was lowered more robustly in the T2D cohort and mainly by week 48 in the obesity trial
GIP receptor activation Further supports insulin secretion in response to meals
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Mutations in particular genes encoding these transportersincluding BSEP ( ABCB11 gene), MDR3 ( ABCB4 gene), sterolin-1 and sterolin-2 ( ABCG5/8 genes), and MRP2 ( ABCC2 gene)result in a wide spectrum of liver diseases, ranging from benign conditions such as Dubin-Johnson syndrome to more severe presentations like progressive familial intrahepatic cholestasis