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They also decreased the expression of genes involved in cholesterol synthesis ( ACAT1 , SREBP-2 , HMGCR , and SQLE ), bile acid synthesis ( LXR and CYP7A1 ), and PCSK9 , while increasing the expression of genes involved in the reverse cholesterol transport pathway ( ABCA1 and SR-B1 ) and low-density lipoprotein cholesterol uptake ( LDLR )
M.WebbS
Oral medications with narrow therapeutic indices require particular attention
These variations can increase the risk of potential safety concerns, including developing serious adverse effects and health risks like kidney and heart disease
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