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For recycling, cells were incubated with agonists at 37 C for 15 min, followed by endocytosis arrest at 4 C, surface label removal as above, 30 min incubation at 37 C with 10 M exendin(9-39) to prevent further internalization, and a second round of surface label removal at 4 C

Journal of Clinical Pharmacology , 64(1), 65-72

In the case of histamine intolerance, the ratio between the breakdown of histamine and its formation in the body or its intake with food is not in balance