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Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways

But the lack of independent replication is a legitimate concern

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Beyond their established role as energy substrates, SCFAs act as localized and systemic signaling molecules through G protein-coupled receptors (GPR41, GPR43, and GPR109A), thereby mediating bidirectional communication between the gastrointestinal tract and peripheral organs 165