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A comparison between the kinetic parameters of mutated ScGrx7 and PfGrx reveals extreme similarities and supports a general applicability of our mechanistic model
The aim of this study was to investigate how A pathology correlates with ferroptosis in human post-mortem brain, and whether ferroptosis inhibition could have a protective effect on A-related pathophysiology
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Les voies molculaires documentes en recherche prclinique incluent : (1) activation de la synthse d'oxyde nitrique (NO) via la voie L-arginine/eNOS, (2) surexpression transcriptionnelle de VEGF-A et FGF-2 favorisant l'angiogense, (3) modulation du facteur de transcription prcoce Egr-1 impliqu dans la prolifration fibroblastique, (4) interaction avec les rcepteurs 5-HT2A et dopaminergiques dans certains modles comportementaux, (5) stabilisation de la fonction endothliale via modulation de la eNOS et rduction du stress oxydatif (8-OH-dG, MDA)
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