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On the one hand, in keratinocytes, ascorbate (100 M) reduces the level of Nrf2 inhibitor, i.e., Keap1 protein, and increases free Nrf2 expression, as well as its activators, including p62 and KAP1, on the other [33,83]

(2011) demonstrated that E2 stimulates the differentiation of fibroblasts into myofibroblasts inducing wound contraction, and increases extracellular matrix deposition and wound tensile strength (Novotn et al., 2011)