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Gln, a nonessential amino acid abundant in the bloodstream, along with its metabolites lutamate and ketoglutarate (-KG), serves as a vital source of carbon and nitrogen, providing essential raw materials for the synthesis of nucleotides and amino acids ( Although some Gln metabolic inhibitors have entered clinical trials, the heterogeneity among tumors complicates their effectiveness

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For researchers prioritizing muscle preservation, a moderate dose of 4 to 8 mg combined with adequate protein intake (1.0 to 1.2 grams per kilogram of body weight) and resistance training appears to optimize the fat-to-lean mass loss ratio

The findings suggest that APO may be used as a potential treatment drug to stop mucositis caused by MTX due to counteracting oxidative stress, inflammatory, and apoptotic pathways