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Tolerance (i.e., need for increased amounts or diminished effect with continued use of the same amount)* Experiencing withdrawal (opioid withdrawal syndrome) or taking opioids (or a closely related substance) to relieve or avoid withdrawal symptoms.* *Patients who are taking opioids as prescribed by a healthcare provider may experience tolerance and withdrawal, but in that case, do not have opioid use disorder

Dangers: Despite its potential benefits, concerns about the unregulated use of TB500 in non-medical settings persist

Advances in Experimental Medicine and Biology, vol 1311

Different FDA-approvals As you now know, the FDA has approved Zepbound for chronic weight management in adults with obesity, indicated by a BMI of 30 kg/m or higher, or in overweight adults with a BMI of 27 kg/m or more who have associated weight-related health issues