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Other GLP-1R, GIPR, and glucagon receptor (GCGR) poly-agonists are in development and have been tested in phase 1 and phase 2 clinical trials, including GLP-1R/GCGR agonists, GLP-1R/GLP-2R agonists, and triple GLP-1R/GIPR/GCGR agonists (abstracts presented at the American Diabetes Association Annual Meeting in June, 2022 and (7))

Tirzepatide: SURMOUNT-1 (72 Weeks) The SURMOUNT-1 trial enrolled 2,539 adults with obesity (BMI 30) or overweight with comorbidities

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GLP-1 medications notoriously disrupt the gut, making this a critical inclusion