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Introduction Somatostatin receptors (SSTRs) are expressed in organs and tissues throughout the body ( 111 In-pentetreotide [Octreoscan] and 177 Lu-DOTATATE) ( Somatostatin is a potent inhibitor of pituitary hormone secretion, including inhibition of growth hormone and adrenocorticotropic hormone (ACTH) secretion ( The lack of efficacy of somatostatin analogs targeting SSTR2 in patients with Cushing disease supports the hypothesis that SSTR2 is downregulated by glucocorticoids

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