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Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat

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The finding that a long-acting GIP receptor agonist (LAGIPRA) increases insulin sensitivity by promoting glucose capture in WAT confirms this

Quantification of IECs double-positive for epithelial cell adhesion molecule (EpCAM) and GLP-1 by flow cytometry showed no differences between Tmprss2 / and WT mice, indicating regulation of GLP-1 secretion (Supplemental Figure 4, C and D)