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Other compounds: GLP-1s like semaglutide, or CJC/ipamorelin, change the picture and make tesamorelin's solo effect hard to judge
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1 Introduction 1.1 Relationship among gut microbiota, TMA and TMAO production, and human diseases Consolidated literature from over the last 20 years confirms the relationship between intestinal microbiota and a series of diseases ( 1.2 Biochemical mechanisms of TMA production Most of the TMA is synthesized in the intestine (colon) by the action of some anaerobic commensal gut bacteria containing choline- (or carnitine-) TMA lyase, an enzyme consisting of two units: a catalytic unit (CutC) and its activating enzyme (CutD) ( etc .), betaine, and L-carnitine and its metabolite -butyrobetaine (GBB), releasing TMA after the cleavage of the carbon (C)nitrogen (N) bond of choline/carnitine ( 1.3 Trimethylaminuria (TMAU): etiology, psychosocial impact, and incidence Trimethylaminuria (TMAU) is caused by TMA accumulation
In vivo studies do not fully clarify whether previous hydrolysis of the protein sources with commercial enzymes leads to stronger GLP-1-secreting effects
