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Zinc is present in every cell in the body and is also a component of over 200 enzymes and involved in more enzymatic reactions than any other mineral constituent in mammals
70 As cells use NADPH to reduce cystine to cysteine, the increased cysteine catabolism by CDO implies the increased consumption of NADPH, which will affect other cell metabolic pathways and the antioxidant capacity as well
Animal studies show that MPs exposure induces structural damage to intestinal villi, reduces crypt numbers, downregulates tight-junction proteins such as ZO1 and Occludin, and thins the mucus layer, resulting in increased intestinal permeability [67]
10.1039/C9CC09207B
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