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Here, we focus on identifying the effect of more nuanced changes in cholesterol content on exendin-4-mediated GLP-1R function in primary islets and in vivo , followed by mapping of cholesterol binding sites for both apo-state and active receptor structures using coarse-grained molecular dynamics (cgMD) simulations tailored to identify lipid-receptor interactions, and functional validation of a prominent site for its effects on cholesterol binding, plasma membrane behaviours and exendin-4-mediated GLP-1R function in beta cells and primary islets

Starting a GLP-1 medication earlier in type 2 diabetes has the potential to not only improve blood sugar and promote weight loss, but also proactively protect the heart, kidneys, nerves, and overall metabolic health

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Orci, L