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This property is exploited by cancer cells, which develop a strong dependence on iron to satisfy the heightened metabolic demands associated with their uncontrolled proliferation and invasive behavior

doi: 10.1007/s004290100186 199 WongCLLeeKHLoKMChanOCGogginsWOWSet al

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25, 38 As aberrations in the TP53 gene and t(4:14) translocations are seen in 15% of patients 49 and correlated with short progression-free survival and resistance to alkylating agents at relapse, 50 the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM