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Circulation 141 , 18001812 (2020)

The deletion of NF-B signalling in microglia rescued motor neurons from microglia-mediated death and prolonged neuronal survival in ALS mice by preventing pro-inflammatory microglial activation ( Neurons and other post-mitotic cells are particularly vulnerable to DNA damage, which results in cell death if left untreated

reported that cleavage products derived from GLP-1 reduced tubulointerstitial renal damage, lowered the expression of tubular injury markers, and attenuated the renal accumulation of macrophages and T cells ( Glycemic Control Although the glucose-independent mechanisms are emphasized, glycemic control by GLP-1RAs is considered to be involved in its renoprotective effects