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From Concentration to Dosing With your stock solution mixed, the next task is figuring out how much to draw for a specific dose, which is often measured in micrograms ( mcg )

| Phase | Dose | Weeks on That Dose | |---|---|---| | Initiation | 0.25 mg weekly | Weeks 1-4 | | First escalation | 0.5 mg weekly | Weeks 5-16 | | Second escalation | 1 mg weekly | Weeks 17-28+ | | Optional third escalation | 2 mg weekly | Week 29 onward | Each dose increase represents a new stimulus to GLP-1 receptors, including those in pancreatic tissue

Results Sitagliptin prevents IKK-NFB signaling pathway We initially mimic the inflammation in vitro with the tumor necrosis factor- (TNF)/LPS stimulation in HepG2 and primary mouse hepatocytes

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