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Tirzepatide may outperform GLP-1 medications because: GIP activation improves insulin signaling Glucose disposal becomes more efficient Fat storage signals are reduced This makes tirzepatide particularly useful for patients with: Prediabetes Type 2 diabetes Visceral fat dominance Can You Switch from a GLP-1 to Tirzepatide

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Overall, formal adjustment for these variables was uncommon, highlighting an important source of heterogeneity across studies

But equally, it is in the f****ing way