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Most clients notice reduced appetite within the first 1-2 weeks

Another study conducted in 158 healthy male volunteers assessed the impact of different water volumes and post-dosing fasting periods on semaglutide exposure, and the authors concluded that administration of oral semaglutide in the fasting state with up to 120 mL of water and a post-dose fasting period of at least 30 min resulted in clinically relevant semaglutide exposure [31]

Semaglutide acts as a GLP-1 receptor agonist, which means it mimics the GLP-1 hormone naturally produced in the intestines

But in two circumstances either if our glycogen stores are full or if our blood glucose levels have been too high for too long we then convert that glucose into fat via the liver into triglycerides, and that type of fat tends to be stored around the middle. Helen says that triathletes are unlikely to suffer from full glycogen stores, but could fall foul of having high blood glucose levels by eating large quantities of carbs in one sitting