doi: 10.1016/j.phrs.2024.107338
These include: Commercial weight management programmes (such as Weight Watchers/WW, Slimming World) that provide group support, structured meal plans, and accountability NHS-funded programmes including the NHS Digital Weight Management Programme, which offers evidence-based support for eligible patients Cognitive behavioural therapy (CBT) approaches that address psychological factors contributing to overeating and weight gain Dietary approaches with good evidence include: Mediterranean-style diets emphasising whole grains, fruits, vegetables, legumes, nuts, olive oil, and moderate fish consumption Low-calorie diets (1,200-1,500 kcal/day for women, 1,500-1,800 kcal/day for men) with balanced macronutrient distribution Very low-calorie diets (800 kcal/day) for short periods under medical supervision, particularly for patients with type 2 diabetes Bariatric surgery represents the most effective intervention for severe obesity (BMI 40 kg/m, or 35 kg/m with comorbidities)
Reasonable monitoring framework for a sermorelin protocol Timepoint Baseline What to check IGF-1, full thyroid panel, fasting glucose, comprehensive metabolic panel Why Establish starting values before therapy and rule out untreated hypothyroidism
For the best results, look for liposomal formulas that prioritize absorption and pair them with heart-healthy lifestyle habits
