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In fact, with the exception of the lowest treatment dose investigated (2.5 mg oral semaglutide), almost 100% of patients experienced a reduction in HbA 1c in the phase II trial, indicating that the variability in semaglutide exposure is not likely to affect the proportion of subjects with a clinically relevant treatment response [10]

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Retrospective cohort studies show that these agents do not increase the risk of IBD flares or gastrointestinal-specific adverse events compared to the general population ( Metabolic outcomes GLP-1RAs consistently yield significant weight loss and glycemic control in patients with IBD and comorbid obesity or diabetes