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The approval of injectable semaglutide for adolescents aged 12 and older in 2022 established a precedent for GLP-1-based weight management in younger patients, and an oral option could substantially change the treatment calculus for this population
This has led to the exploration of a potential connection between incretin hormones and bone tissue, referred to as the entero-endocrine-osseous axis
Until recently, therapeutic strategies remained limited to lifestyle interventions, with few pharmacological options demonstrating meaningful clinical benefit
The most commonly reported side effects of L-carnitine supplements are gastrointestinal, including nausea, stomach cramps, diarrhoea, and a distinctive fishy body odour caused by the production of trimethylamine during gut metabolism
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