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Bepranemab, a monoclonal antibody against the microtubule-binding region, showed biomarker improvement in a Phase 2 study that ended in 2024, but people enrolled in the trial had no change in cognition

cDNA-based overexpression screen The SLC-focused cDNA overexpression library was generated previously (Wolf et al, manuscript submitted) by amplifying the codon-optimized cDNAs of 452 SLCs, the ABC transporters ABCC1, ABCB1, and ABCF2, eGFP, and a constitutively active MLKL variant (MLKLS358D) from pDONR221 plasmids (www.addgene.org/RESOLUTE_Consortium) with primers containing 10-bp barcodes (Table S3)

[DOI] [PubMed] [Google Scholar] 78.Tennstedt P., Peisker D., Bottcher C., Trampczynska A., Clemens S

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