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While Mc4r KO mice treated with PL7737 showed no significant decline in food intake or weight, DIO mice treated with PL7737 demonstrated significantly reduced food intake and significantly reduced body weight by 7.06% compared to the vehicle group, confirming the metabolic effects of PL7737 require intact MC4R signaling

It becomes more difficult to exercise and stick to a diet plan

Administer tesamorelin at night

Physical performance Ask whether the patient is: Walking more slowly Avoiding stairs Struggling to rise from a chair Falling or nearly falling Losing independence with daily activities Unable to complete usual exercise Becoming progressively fatigued with routine tasks 5