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The vitamin's role in homocysteine metabolism is particularly relevantdeficiency leads to elevated homocysteine levels and methylmalonic acid, which may contribute to neurological dysfunction

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141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2

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