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41 Functionally, in response to polyinosinic:polycytidylic acid stimulation, E-cig exposed AMs exhibited decreased expression of interferon (INF) response factor 7, a principal transcription factor in the regulation of type 1 IFN production in the presence of viral stimuli

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The use of an objective laboratory marker of alcohol use is not novel and has been recommended for all alcohol treatment trials [52], but this will be the first topiramate trial to utilise phosphatidylethanol for this purpose

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