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Cell Stem Cell 23 , 544556.e544 (2018)
The most common signs and symptoms are: Muscle tremors Postural instability and impaired balance (difficulty remaining upright especially when standing still or rising from a chair) Difficulty with walking, often taking shuffling (festinating) steps, Slowness of movements (bradykinesia) Inability to get movements going (akinesia) Sustained or repeated muscle cramp (dystonia) Stiffness of muscle movement (rigidity) Stooped posture (due to being postural unstable so then subconsciously lowering ones center of gravity to compensate) Increased postural sway (body motion when standing still) Loss of smell Sleep disturbances
Dias I, Costa RGA,Rodrigues A, Silva SLR,Oliveira MS,Soares MBP,Dias RB, Valverde LF, Gurgel Rocha CA
