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Specific dipeptide and tripeptide sequences (particularly hydroxyproline-proline, proline-hydroxyproline, and glycine-proline-hydroxyproline) have been identified as bioactive signals that directly stimulate fibroblasts to upregulate collagen and hyaluronic acid production

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These results show how Melanotan peptides help scientists explore pigmentation, hormonal signaling, and receptor function more deeply by providing experimental insight into how melanocortin receptors operate in different tissues