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The coagulation system activates in response to vascular injury and prevents hemorrhage, while the fibrinolytic system dissolves blood clots and intravascular thrombi, preventing thrombosis
Over time, it can cause irreversible nerve damage, cognitive decline, and mental health disorders such as depression
Prescribing outside the licensed indications and doses constitutes off-label use, which requires prescribers to document their rationale, obtain informed consent, and provide appropriate monitoring
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