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21 Plasma PLP values 4 ng/mL have been reported in 57% of alcoholic patients with no evident hepatic or hematologic manifestations

The improved functioning of the BBB, enhanced clearance of metabolites and protein fragments implicated in AD from the brain - an astrocyte-dependent mechanism primarily occurring during sleep [14] - and enhanced insulin signaling, suggested to play a role in AD [33], present additional mechanisms by which melatonin may impact AD pathology

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Higher glutathione levels are consistently associated with reduced cardiovascular risk