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Using the meta-regressionBayesian, regularized, trimmed (MR-BRT) tool, we estimated a pooled relative risk for each outcome that incorporated significant sources of systematic bias, within-study correlation, and between-study heterogeneity 18

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The convergence of acetaldehyde-producing fungi, oncoviral cofactors (HPV/EBV), and nitrosamine-enriched bacterial consortia establishes a polymicrobial carcinogenic milieu, necessitating functional metagenomic studies to disentangle microbial contributions to OSCC progression and targeted interventions to restore mucosal homeostasis